CONGENITAL AND HEREDITARY PATHOLOGY IN WOMEN CONTRACTED COVID-19 DURING PREGNANCY
Keywords:
pregnancy, congenital anomaly, hereditary diseases, prenatal diagnostics, СОVID-19.
Abstract
The study aimed to investigate the frequency and structure of congenital and hereditary pathologies identified through non-invasive and invasive methods of prenatal diagnostics in women who contracted COVID-19 during pregnancy, among the population of the Lviv region. The data from prenatal diagnostics results of congenital developmental defects in non-invasive prenatal diagnostics and hereditary diseases in invasive prenatal diagnostics were analyzed in women who contracted COVID-19 during pregnancy. The study demonstrated that the frequency of diagnosing congenital anomalies (CA) in the fetus among 159 pregnant women in non-invasive prenatal diagnostics (PND) was 13.8%. In the structure of congenital anomalies, facial anomalies were the most prevalent, accounting for 5.0% in the first position, followed by anomalies of the cardiovascular system at 2.5% in the second position, anomalies of the skeletal system at 2.5% in the third position, and multiple congenital anomalies at 1.9% in the fourth position. Invasive prenatal diagnostics were performed on 12.6% of women in this group, with chromosomal pathology detected in 5.0% of women: trisomy 21 was diagnosed in 3.8%, Turner syndrome in 1.3%, and a normal karyotype was identified in 7.5% of patients. The frequency of chromosomal pathology in women who contracted COVID-19 during pregnancy was 5.0%. The results of this study will contribute to the improvement of effective medical-genetic counseling and the prediction of healthy offspring.
References
1. Zaporozhan V.M., Mishchenko V.P., Rudenko I.V. (2012). Suchasni aspekty profilaktyky hestatsiinykh uskladnen [Modern aspects of prevention of gestational complications]. Zhurnal natsionalnoi akademii medychnykh nauk Ukrainy. 18. 3: 372 – 378. [in Ukrainian].
2. Tymonina M.B. (2016). Naselennia Ukrainy na 2015 rik. [Population of Ukraine for 2015] Demohrafichnyi shchorichnyk. Derzhavna sluzhba statystyky Ukrainy. Kyiv. 119 s. [in Ukrainian].
3. Pidvysotska N.I. (2015). Suchasni pryntsypy ta problemy medyko-henetychnoho konsultuvannia [Modern principles and problems of medical genetic counseling] Klinichna ta eksperymentalna patolohiia. ХІV. 2(52): 244-247. [in Ukrainian]. [in Ukrainian].
4. Lazoryshynets V.V. (2016). Taktyko-stratehichni pytannia ukrainskoi kardiokhirurhii ta interventsiinoi kardiolohii yak efektyvnykh instrumentiv zabezpechennia suchasnoho rivnia dopomohy naselenniu z sertsevo-sudynnymy zakhvoriuvanniamy [Tactical-strategic issues of Ukrainian cardiac surgery and interventional cardiology as effective tools for ensuring a modern level of care for the population with cardiovascular diseases]. Visnyk sertsevo-sudynnoi
khirurhii. 3 (26):9–10. [in Ukrainian].
5. Verteletskyi V., Yevtushok B., Zymak-Zakutnia N.V. (2016) Vrodzheni vady rozvytku, Polissia, Chornobyl [Congenital malformations, Polissya, Chernobyl] Neonatolohiia, khirurhiia ta perynatalna medytsyna. VI, 2 (20):5–14. [in Ukrainian].
6. Medvedev, M.V., Davydova, Yu.V.(2016). Profilaktika perinatalnyh poter: na puti k personalizirovannoj medicine. [Prevention of perinatal losses: on the way to personalized medicine]. Perinatologiya i pediatriya. 1: 59–67. [in Ukrainian].
7. Safonova I.N. (2016). Opredelenie stepeni perinatalnogo riska po rezultatam antenatalnyh ehograficheskih monitoringov [Determination of the degree of perinatal risk based on the results of antenatal echographic monitoring]. Perinatologiya ta pediatriya. 3: 76–84. [in Ukrainian].
8. Sonja A. Rasmussen, John C. Smulian, John A. Lednicky; Tony S. Wen, Denise J. Jamieson. Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians needtoknow. (2020) American Journal of Obstetrics & Gynecology, 222; 5: 415–426.
9. Dehan Liu, Lin Li, Xin Wu, Dandan Zheng, Jiazheng Wang, Lian Yang, Chuansheng Zheng, Liu D, Li L, Wu X, et al. (2020). Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: a preliminary analysis. AJR . 215:127–132.
10. Sudheer R. Gorla, Abhishek Chakraborty, Ashish Garg, Rubee A. Gugol. (2019). Emerging trends in the prenatal diagnosis of complex CHD and its influence on infant mortality in this cohort. Cardiology in the Young. Get access. 29, 3: 270–276.
11. Heather Y, James A, Rachel T. (2018). Prenatal detection of critical cardiac outflow tract anomalies remains suboptimal despite revised obstetrical imaging guidelines. National Institutes of Health. Grant Number: UL1TR001442. 13; I. 5:748-756.
12. Wong S.F., Chow K.M., Leung T.N., Ng W.F., Ng T.K., Shek C.C. et al. (2004). Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol. 191(1):2927.
13. Huang C, Wang Y, Li X et al. (2020). Clinical features of patients in fected with 2019 novel coronavirus in Wuhan, China. Lancet; published online Jan 24. https://doi.org/10.1016/S01406736(20)301835.
14. Lei D.W.C., Li C, Fang C, Yang W et.al. (2020). Clinical characteristics of pregnancy withthe 2019 novel coronavirus disease (COVID19) infection. Chinese Journal Perinatal Medicine. 23(3).
15. Wastnedge E.A.N., Reynolds R.M., van Boeckel S.R., Stock S.J., Denison F.C., Maybin J.A., Critchley H.O.D.(2021) Pregnancy and COVID-19. Physiol Rev 101: 303–318. doi: 10.1152/physrev.00024.2020.
16. Guo Z-D., Wang Z-Y., Zhang S-F., Li X., Li L., Li C. et al. (2020). Aerosol and surface distribution of severe acute respiratory syndrome coronavirus 2 in hospital wards, Wuhan, China, 2020. Emerg Infect Dis 26: 1583–1591. doi:10.3201/ eid2607.200885.
17. Bourne T., Kyriacou C., Coomarasamy A., Al-Memar M., Leonardi M., Kirk E. (2020). ISUOG Consensus Statement on rationalization of early-pregnancy care and provision of ultrasonography in context of SARS-CoV-2. Ultrasound Obstet Gynecol. 55: 871–878. doi:10.1002/uog.22046.
18. Poon L.C., Yang H., Kapur A., Melamed N., Dao B., Divakar H. et al. (2020). Global interim guidance on coronavirus disease 2019 (COVID-19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals. Int J Gynaecol Obstet 149: 273–286. doi:10.1002/ijgo.13156.
19. Cascella M., Rajnik M., Cuomo A., Dulebohn S.C., Di Napoli R. (2020). Features, Evaluation and Treatment Coronavirus (COVID-19). Access mode: https://www.ncbi.nlm.nih.gov/pubmed/ 32150360.
20. Di Mascio D., Khalil A., Saccone G., Rizzo G., Buca D., Liberati M. et al. (2020). Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2: 100107. doi:10.1016/j.ajogmf.2020.100107.
21. Safonova I.M. (2015). Postnatalni klinichni rezultaty riznykh ekhohrafichnykh variantiv anomalii sechovydylnoi systemnoi plody: ohliad literatury ta analiz serii vypadok. (Ohliad literatury ta analiz serii vypadkiv). [Postnatal clinical outcomes of different ultrasound variants of fetal urinary tract abnormalities: literature review and case series analysis. (Literature review and case series analysis)]. Ukrainskyi radiolohichnyi zhurnal. 23; 1: 80-83.
22. Hrabar V.V. (2015). Alhorytmy prekontseptsiinoho i prenatalnoho monitorynhu v rodynakh z porushenniamy reproduktyvnoi funktsii [ Algorithms of preconceptional and prenatal monitoring in families with disorders of reproductive function]. Visnyk problem biolohii i medytsyny. 1: 121–126.
23. Nikolenko M.І., Arbuzova S.B. (2018). Rannie prohnozuvannia perynatalnykh uskladnen u ramkakh tradytsiinoho prenatalnoho skryninhu vahitnykh. Pytannia na chasi [Early prediction of perinatal complications within the traditional prenatal screening of pregnant women. The question is timely]. Z turbotoiu pro zhinku. 4:27–29. [in Ukrainian].
24. Begimbekova L.M., Alieva E.N., Sulejmenova Zh.U., Tastanbekova Sh.A. Bajkubekova A.U. (2015) Optimizaciya prenatalnoj diagnostiki vrozhdennyh porokov razvitiya ploda i voprosy prognozirovaniya.[Optimization of prenatal diagnosis of congenital malformations of the fetus and issues of prognosis]. Vestnik Kazahskogo Nacionalnogo medicinskogo universiteta. 2:6–8. [in Kazahstan].
25. Pasiieshvili, N.M. (2016). Analiz perynatalnoi zakhvoriuvanosti ta smertnosti v umovakh perynatalnoho tsentru ta shliakhy yii znyzhennia. [Analysis of perinatal morbidity and mortality in the conditions of the perinatal center and ways to reduce it]. Science Rise. 1; 3 (18): 37–43. [in Ukrainian].
26. Prokopchuk N., Nikolenko M., Korinets Ya., Ivaniv Yu. (2023). Otsinka rezultativ prenatalnoi diahnostyky vrodzhenykh vad rozvytku plodu u zhinok v rizni terminy hestatsii [Evaluation of the results of prenatal diagnosis of congenital malformations of the fetus in women at different periods of gestation. Perspektyvy ta innovatsii nauky (Rubryka «Medytsyna»). 10(28): 796–808. [in Ukrainian].
27. Loane M, Dolk H, Kelly A. (2011). EUROCAT statistical monitoring: identification and investigation of ten year trends of congenital anomalies in Europe. Birth defects Res. A Clin. Mol. Teratol. 91: 31–43.
28. Kovalenko O.S., Lepokhina H.S., Zazarkhov O.Iu., Zlepko S.M. (2016). Klasyfikatsiia ryzykiv perynatalnoho periodu zhyttia novonarodzhenykh [Classification of risks of the perinatal period of life of newborns] Environment & Health. 4: 52–54. [in Ukrainian].
29. Antipkin Y.G., Volosovets O.P., Maidannik O.P., Berezenko V.S., Moiseenko R.O. (2018). Stan zdorovia dytiachoho naselennia – maibutnie krainy. [The state of health of children is the future of the country]. Zdorov'e rebenka. 1: 11–21. [in Ukrainian].
30. Kostiuk O.O., Shunko Ye.Ye. (2020). Mama ta dytyna v umovakh svitovoi pandemii koronavirusnoi infektsii. Novi vyklyky dlia systemy okhorony zdorovia [Mother and child in world conditions pandemic of coronavirus infection. New challenges for the healthcare system] Ukrainskyi zhurnal perynatolohiia i pediatriia. 2:17–26. [in Ukrainian].
2. Tymonina M.B. (2016). Naselennia Ukrainy na 2015 rik. [Population of Ukraine for 2015] Demohrafichnyi shchorichnyk. Derzhavna sluzhba statystyky Ukrainy. Kyiv. 119 s. [in Ukrainian].
3. Pidvysotska N.I. (2015). Suchasni pryntsypy ta problemy medyko-henetychnoho konsultuvannia [Modern principles and problems of medical genetic counseling] Klinichna ta eksperymentalna patolohiia. ХІV. 2(52): 244-247. [in Ukrainian]. [in Ukrainian].
4. Lazoryshynets V.V. (2016). Taktyko-stratehichni pytannia ukrainskoi kardiokhirurhii ta interventsiinoi kardiolohii yak efektyvnykh instrumentiv zabezpechennia suchasnoho rivnia dopomohy naselenniu z sertsevo-sudynnymy zakhvoriuvanniamy [Tactical-strategic issues of Ukrainian cardiac surgery and interventional cardiology as effective tools for ensuring a modern level of care for the population with cardiovascular diseases]. Visnyk sertsevo-sudynnoi
khirurhii. 3 (26):9–10. [in Ukrainian].
5. Verteletskyi V., Yevtushok B., Zymak-Zakutnia N.V. (2016) Vrodzheni vady rozvytku, Polissia, Chornobyl [Congenital malformations, Polissya, Chernobyl] Neonatolohiia, khirurhiia ta perynatalna medytsyna. VI, 2 (20):5–14. [in Ukrainian].
6. Medvedev, M.V., Davydova, Yu.V.(2016). Profilaktika perinatalnyh poter: na puti k personalizirovannoj medicine. [Prevention of perinatal losses: on the way to personalized medicine]. Perinatologiya i pediatriya. 1: 59–67. [in Ukrainian].
7. Safonova I.N. (2016). Opredelenie stepeni perinatalnogo riska po rezultatam antenatalnyh ehograficheskih monitoringov [Determination of the degree of perinatal risk based on the results of antenatal echographic monitoring]. Perinatologiya ta pediatriya. 3: 76–84. [in Ukrainian].
8. Sonja A. Rasmussen, John C. Smulian, John A. Lednicky; Tony S. Wen, Denise J. Jamieson. Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians needtoknow. (2020) American Journal of Obstetrics & Gynecology, 222; 5: 415–426.
9. Dehan Liu, Lin Li, Xin Wu, Dandan Zheng, Jiazheng Wang, Lian Yang, Chuansheng Zheng, Liu D, Li L, Wu X, et al. (2020). Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: a preliminary analysis. AJR . 215:127–132.
10. Sudheer R. Gorla, Abhishek Chakraborty, Ashish Garg, Rubee A. Gugol. (2019). Emerging trends in the prenatal diagnosis of complex CHD and its influence on infant mortality in this cohort. Cardiology in the Young. Get access. 29, 3: 270–276.
11. Heather Y, James A, Rachel T. (2018). Prenatal detection of critical cardiac outflow tract anomalies remains suboptimal despite revised obstetrical imaging guidelines. National Institutes of Health. Grant Number: UL1TR001442. 13; I. 5:748-756.
12. Wong S.F., Chow K.M., Leung T.N., Ng W.F., Ng T.K., Shek C.C. et al. (2004). Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol. 191(1):2927.
13. Huang C, Wang Y, Li X et al. (2020). Clinical features of patients in fected with 2019 novel coronavirus in Wuhan, China. Lancet; published online Jan 24. https://doi.org/10.1016/S01406736(20)301835.
14. Lei D.W.C., Li C, Fang C, Yang W et.al. (2020). Clinical characteristics of pregnancy withthe 2019 novel coronavirus disease (COVID19) infection. Chinese Journal Perinatal Medicine. 23(3).
15. Wastnedge E.A.N., Reynolds R.M., van Boeckel S.R., Stock S.J., Denison F.C., Maybin J.A., Critchley H.O.D.(2021) Pregnancy and COVID-19. Physiol Rev 101: 303–318. doi: 10.1152/physrev.00024.2020.
16. Guo Z-D., Wang Z-Y., Zhang S-F., Li X., Li L., Li C. et al. (2020). Aerosol and surface distribution of severe acute respiratory syndrome coronavirus 2 in hospital wards, Wuhan, China, 2020. Emerg Infect Dis 26: 1583–1591. doi:10.3201/ eid2607.200885.
17. Bourne T., Kyriacou C., Coomarasamy A., Al-Memar M., Leonardi M., Kirk E. (2020). ISUOG Consensus Statement on rationalization of early-pregnancy care and provision of ultrasonography in context of SARS-CoV-2. Ultrasound Obstet Gynecol. 55: 871–878. doi:10.1002/uog.22046.
18. Poon L.C., Yang H., Kapur A., Melamed N., Dao B., Divakar H. et al. (2020). Global interim guidance on coronavirus disease 2019 (COVID-19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals. Int J Gynaecol Obstet 149: 273–286. doi:10.1002/ijgo.13156.
19. Cascella M., Rajnik M., Cuomo A., Dulebohn S.C., Di Napoli R. (2020). Features, Evaluation and Treatment Coronavirus (COVID-19). Access mode: https://www.ncbi.nlm.nih.gov/pubmed/ 32150360.
20. Di Mascio D., Khalil A., Saccone G., Rizzo G., Buca D., Liberati M. et al. (2020). Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2: 100107. doi:10.1016/j.ajogmf.2020.100107.
21. Safonova I.M. (2015). Postnatalni klinichni rezultaty riznykh ekhohrafichnykh variantiv anomalii sechovydylnoi systemnoi plody: ohliad literatury ta analiz serii vypadok. (Ohliad literatury ta analiz serii vypadkiv). [Postnatal clinical outcomes of different ultrasound variants of fetal urinary tract abnormalities: literature review and case series analysis. (Literature review and case series analysis)]. Ukrainskyi radiolohichnyi zhurnal. 23; 1: 80-83.
22. Hrabar V.V. (2015). Alhorytmy prekontseptsiinoho i prenatalnoho monitorynhu v rodynakh z porushenniamy reproduktyvnoi funktsii [ Algorithms of preconceptional and prenatal monitoring in families with disorders of reproductive function]. Visnyk problem biolohii i medytsyny. 1: 121–126.
23. Nikolenko M.І., Arbuzova S.B. (2018). Rannie prohnozuvannia perynatalnykh uskladnen u ramkakh tradytsiinoho prenatalnoho skryninhu vahitnykh. Pytannia na chasi [Early prediction of perinatal complications within the traditional prenatal screening of pregnant women. The question is timely]. Z turbotoiu pro zhinku. 4:27–29. [in Ukrainian].
24. Begimbekova L.M., Alieva E.N., Sulejmenova Zh.U., Tastanbekova Sh.A. Bajkubekova A.U. (2015) Optimizaciya prenatalnoj diagnostiki vrozhdennyh porokov razvitiya ploda i voprosy prognozirovaniya.[Optimization of prenatal diagnosis of congenital malformations of the fetus and issues of prognosis]. Vestnik Kazahskogo Nacionalnogo medicinskogo universiteta. 2:6–8. [in Kazahstan].
25. Pasiieshvili, N.M. (2016). Analiz perynatalnoi zakhvoriuvanosti ta smertnosti v umovakh perynatalnoho tsentru ta shliakhy yii znyzhennia. [Analysis of perinatal morbidity and mortality in the conditions of the perinatal center and ways to reduce it]. Science Rise. 1; 3 (18): 37–43. [in Ukrainian].
26. Prokopchuk N., Nikolenko M., Korinets Ya., Ivaniv Yu. (2023). Otsinka rezultativ prenatalnoi diahnostyky vrodzhenykh vad rozvytku plodu u zhinok v rizni terminy hestatsii [Evaluation of the results of prenatal diagnosis of congenital malformations of the fetus in women at different periods of gestation. Perspektyvy ta innovatsii nauky (Rubryka «Medytsyna»). 10(28): 796–808. [in Ukrainian].
27. Loane M, Dolk H, Kelly A. (2011). EUROCAT statistical monitoring: identification and investigation of ten year trends of congenital anomalies in Europe. Birth defects Res. A Clin. Mol. Teratol. 91: 31–43.
28. Kovalenko O.S., Lepokhina H.S., Zazarkhov O.Iu., Zlepko S.M. (2016). Klasyfikatsiia ryzykiv perynatalnoho periodu zhyttia novonarodzhenykh [Classification of risks of the perinatal period of life of newborns] Environment & Health. 4: 52–54. [in Ukrainian].
29. Antipkin Y.G., Volosovets O.P., Maidannik O.P., Berezenko V.S., Moiseenko R.O. (2018). Stan zdorovia dytiachoho naselennia – maibutnie krainy. [The state of health of children is the future of the country]. Zdorov'e rebenka. 1: 11–21. [in Ukrainian].
30. Kostiuk O.O., Shunko Ye.Ye. (2020). Mama ta dytyna v umovakh svitovoi pandemii koronavirusnoi infektsii. Novi vyklyky dlia systemy okhorony zdorovia [Mother and child in world conditions pandemic of coronavirus infection. New challenges for the healthcare system] Ukrainskyi zhurnal perynatolohiia i pediatriia. 2:17–26. [in Ukrainian].
Abstract views: 59 PDF Downloads: 33
Published
2024-03-05
How to Cite
Korinets, Y., & Prokopchuk, N. (2024). CONGENITAL AND HEREDITARY PATHOLOGY IN WOMEN CONTRACTED COVID-19 DURING PREGNANCY. Scientific Journal of Polonia University, 61(6), 158-167. https://doi.org/10.23856/6120
Section
HEALTH, ENVIRONMENT, DEVELOPMENT
