MODELING THE EFFECTS OF LEAD POLLUTION ON LACTATE DEHYDROGENASE ACTIVITY

Olena Konovalova

doi:10.23856/3305

Olena Konovalova V. N. Karazin Kharkiv National University http://orcid.org/0000-0002-6681-4088

Keywords: heavy metals, lead, manganese, lactate dehydrogenase.

Abstract

The changes of activity of LDH and its isoenzymatic fractions under load with lead acetate are described. The introduction of a subacute dose of Pb^{2 +} led to a decrease in the LDH activity of the rat liver and an increase in the heart. Preliminary introduction of small doses of Pb^{2 +} partially prevents increased LDH activity in the heart and completely inhibits its increase in the liver. The proportion of urea-stable fraction in the heart and blood serum is significantly increased, indicating an increase in the aerobic direction of energy metabolism. The obtained results are the experimental substantiation of further investigations of influence mechanism of heavy metals on the organism, as well as the motivation to prevent environmental pollution by man-made xenobiotics.

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