CLINICAL AND NEUROLOGICAL PECULIARITIES OF LYME DISEASE
Keywords:
Lyme borreliosis, neuroborreliosis, serological tests, neurological features, migratory erythema
Abstract
Goals of our research work are to analyze frequency and prevalence of Lyme borreliosis (LB), to understand engagement of nervs system in pathological process. Also to assess clinical Lyme disease (LD) stages, features, diagnosis, treatment and prevention methods based on the collected data and literature. The data on diagnosis, treatment, prevention of LD and neuroborreliosis (LNB) are carefully gathered from international and domestic publications at PubMed over 2015-2020 years. LB has stages in the course of the disease. The clinical manifestations of this disease are different. LD affects the central and peripheral nervs system, has a multiorgan character, possibly an acute and chronic course of the disease. At the moment, there are various methods for the diagnosis, treatment and prevention of LB, but pathogenesis of the disease has not been sufficiently studied, methods of vaccination have not yet been developed. Damage of nervs system in chronic LD requires further study of the pathogenetic mechanisms and factors of the development of this pathology.
References
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25. Miklossy, J., Khalili, K., Gern, L., Ericson, R., Darekar, P., Bolle, L., et al. (2004). Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease. Journal of Alzheimer's disease, 6, 639-649.
26. Mygland, A., Ljøstad, U., Fingerle, V., Rupprecht, T., Schmutzhard, E., Steiner, I., et al. (2018). EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. European journal of neurology, 17(1), 8-16.
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28. Pachner, A.R., & Steere, A.C. (1995). The triad of neurologic mani-festations of Lyme disease: meningitis, cranial neuritis and radiculoneuritis. Journal of Neurology, 35, 47-53.
29. Popovych, O.O. (2006). Laim-borelioz: suchasna problema infektolohii [Lyme disease: modern problems of infectology]. Aktualna infektolohiia – Topical infectology, 3, 114-122 [in Ukrainian].
30. Rauer, S., Kastenbauer, S., Fingerle, V., Hunfeld, K., Huppertz, H., & Dersch, R. (2018). Lyme Neuroborreliosis. Deutsches Ärzteblatt international, 115(45), 751–756.
31. Reimers, C.D., Neubert, U., Kristoferitsch, W., & Mayr, W.R. (1992). Borrelia burgdorferi infection in Europe: an HLA-related disease? Infection, 20(4), 197-200.
32. Saccomano, S.J., & Hrelic, D.A. (2018). Recognizing and treating Lyme disease. The Nurse practitioner, 43(8), 13-21.
33. Spirin, N.N., Baranova, N.S., Fadeeva, O.A., & Shipova, E.G. (2012). Algoritm differencialnoj diagnostiki rasseyannogo skleroza i hronicheskogo borrelioznogo encefalomielita [Algorithm for differential diagnosis of multiple sclerosis and chronic borreliosis encephalomyelitis]. Nevrologicheskij zhurnal – Neurological journal, 4, 31-36 [in Russian].
34. Wackernagel, A., Bergmann, A. R. & Aberer, E. (2005). Acute exacerbation of systemic scleroderma in Borrelia burgdorferi infection. The Journal of the European Academy of Dermatology and Venereology, 19, 93-96.
35. Wang, E., Shirvalkar, P.R. & Maciel, C.B. (2014). American neuroborreliosis presenting as cranial polyneuritis and radiculoneuritis. Neurology Neuroimmunology & Neuroinflammation, 1(3), 420-423.
36. Zinchuk, O.M. (2010). Laim-borelioz: kliniko-imunopatohenetychni osoblyvosti ta ekstrene preventyvne likuvannia [Lyme borreliosis: clinical and immunopathogenetic features and emergency preventive treatment]. Extended abstract of Doctor’s thesis. Kyiv [in Ukrainian].
2. Bremell, D., & Dotevall, L. (2014). Oral doxycycline for Lyme neuroborreliosis with symptoms of encephalitis, myelitis, vasculitis or intracranial hypertension. European journal of neurology, 21(9), 1162-1167.
3. Bremell, D., & Hagberg, L. (2011). Clinical characteristics and cerebrospinal fluid parameters in patients with peripheral facial palsy caused by Lyme neuroborreliosis compared with facial palsy of unknown origin (Bell's palsy). BMC Infectious Diseases, 11, 215-225.
4. Bush, L.M., & Vazquez-Pertejo, M.T. (2018). Tick borne illness-Lyme disease. Disease-a-Month Journal, 64 (5), 195-212.
5. Cameron, D. J., Johnson, L.B., & Maloney, E.L. (2016). Evidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease. Expert review of anti-infective therapy, 12(9), 1103-1135.
6. Centralized Information System for Infectious Diseases of the WHO Regional Office for Europe [Text]. (n.d.). data.euro.who.int/cisid. Retrieved from http://data.euro.who.int/cisid.
7. Dersch, R., Sommer, H., Rauer, S., & Meerpohl, J. (2016). Prevalence and spectrum of residual symptoms in Lyme neuroborreliosis after pharmacological treatment: a systematic review. Journal of neurology, 263(1), 17-24.
8. Halperin, J.J., Volkman, D.J., & Wu, P. (1991). Central Nervos system abnormalities in Lyme neuroborreliosis. Neurology, 41(10), 1571-1582.
9. Hansen, K., & Lebech, A.M. (1991). Lyme neuroborreliosis: a new sensitive diagnostic assay for intrathecal synthesis of Borrelia burgdorferi--specific immunoglobulin G, A, and M. Annals of Neurology, 30 (2), 197-205.
10. Infektsiinyi biuleten pro stan infektsiinoi zakhvoriuvanosti v Ukraini [Infectious bulletin on the state of infectious diseases in Ukraine]. (2016). www.dsesu.gov.ua. Retrieved from http://www.dsesu.gov.ua [in Ukrainian].
11. Izquierdo, G., & Aguilar, J. (1992). Validity of positive anti-Borrelia antibodies in patients with neuroborreliosis. Neurologia, 7(7), 198- 199.
12. Johnson, B. J., Pilgar, M.A., & Russel, T.M. (2014). Assessment of new culture method for detection of Borrelia species from serum of lyme disease patients. Journal of clinical microbiology, 52(3), 721-724.
13. Kaya, A.D., Parlak, A.H., Ozturk, C.E., & Behcet, M. (2008). Seroprevalence of Borrelia burgdorferi infection among forestry workers and farmers in Duzce, north-western Turkey. The new microbiologica, 31(2), 203-209.
14. Koedel, U., & Pfister, H. (2017). Lyme neuroborreliosis. Current opinion in infectious diseases, 30(1), 101-107.
15. Kortela, E., Hytönen, J., Numminen, J., Overmyer, M., Saxen, H., & Oksi J. (2017). Cerebral vasculitis and intracranial multiple aneurysms in a child with Lyme neuroborreliosis. JMM Case Reports, 4, 217-230.
16. Krause, A., & Fingerle, V. (2009). [Lyme borreliosis] [Article in German]. Zeitschrift für Rheumatologie, 68(3), 239-252.
17. Kravchuk, L.N., Kuvshinov, Yu.V., & Sergovskaya, V.D. (1992). Seroznye meningity pri borrelioze Lajma [Serous meningitis in Lyme borreliosis]. Zhurnal nevropatologii i psihiatrii – Journal of Neuropathology and Psychiatry, 92, 41-44 [in Russian].
18. Krupp, L.B., Masur, D., Schwartz, J., Coyle, P.K, Langenbach, L.J., Fernquist, S.K., et al. (1991). Cognitive functioning in late Lyme borreliosis. Archives of neurology, 48(11), 1125-1129.
19. Kuntzer, T., Bogousslavsky, J., Miklossy, J., Steck, A.J., Janzer, R., & Regli, F. (1991). Borrelia rhombencephalomyelopathy. Archives of neurology, 48(8), 832-836.
20. Lantos, P.M. (2015). Chronic Lyme disease. Infectious disease clinics of North America, 29, 325-340.
21. Mancardi, G.L., Del Sette, M., & Primarera, A. (1989). Borrelia burgdorferi infection and Guillain-Barre sindrome. Lancet, 2 (8669), 985-986.
22. Matschke, H., & Durch, J. (1987). [Neurologic diseases transmitted by ticks] [Article in German].
23. Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete, 7, 192-195.
24. Middelveen, M.J., Sapi, E., Burke, J., Filush, K.R., Franco, A., Fesler, M.C., et al. (2018). Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease. Healthcare (Basel, Switzerland), 6(2), 33-39.
25. Miklossy, J., Khalili, K., Gern, L., Ericson, R., Darekar, P., Bolle, L., et al. (2004). Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease. Journal of Alzheimer's disease, 6, 639-649.
26. Mygland, A., Ljøstad, U., Fingerle, V., Rupprecht, T., Schmutzhard, E., Steiner, I., et al. (2018). EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. European journal of neurology, 17(1), 8-16.
27. Nakaz MOZ Ukrainy № 218 «Pro posylennia zakhodiv diahnostyky ta profilaktyky iksodovykh klishchovykh borelioziv v Ukraini» [Order of the Ministry of Health of Ukraine № 218 «On strengthening measures for diagnosis and prevention of Ixodes tick-borne borreliosis in Ukraine»]. (2005). Kyiv [in Ukrainian].
28. Pachner, A.R., & Steere, A.C. (1995). The triad of neurologic mani-festations of Lyme disease: meningitis, cranial neuritis and radiculoneuritis. Journal of Neurology, 35, 47-53.
29. Popovych, O.O. (2006). Laim-borelioz: suchasna problema infektolohii [Lyme disease: modern problems of infectology]. Aktualna infektolohiia – Topical infectology, 3, 114-122 [in Ukrainian].
30. Rauer, S., Kastenbauer, S., Fingerle, V., Hunfeld, K., Huppertz, H., & Dersch, R. (2018). Lyme Neuroborreliosis. Deutsches Ärzteblatt international, 115(45), 751–756.
31. Reimers, C.D., Neubert, U., Kristoferitsch, W., & Mayr, W.R. (1992). Borrelia burgdorferi infection in Europe: an HLA-related disease? Infection, 20(4), 197-200.
32. Saccomano, S.J., & Hrelic, D.A. (2018). Recognizing and treating Lyme disease. The Nurse practitioner, 43(8), 13-21.
33. Spirin, N.N., Baranova, N.S., Fadeeva, O.A., & Shipova, E.G. (2012). Algoritm differencialnoj diagnostiki rasseyannogo skleroza i hronicheskogo borrelioznogo encefalomielita [Algorithm for differential diagnosis of multiple sclerosis and chronic borreliosis encephalomyelitis]. Nevrologicheskij zhurnal – Neurological journal, 4, 31-36 [in Russian].
34. Wackernagel, A., Bergmann, A. R. & Aberer, E. (2005). Acute exacerbation of systemic scleroderma in Borrelia burgdorferi infection. The Journal of the European Academy of Dermatology and Venereology, 19, 93-96.
35. Wang, E., Shirvalkar, P.R. & Maciel, C.B. (2014). American neuroborreliosis presenting as cranial polyneuritis and radiculoneuritis. Neurology Neuroimmunology & Neuroinflammation, 1(3), 420-423.
36. Zinchuk, O.M. (2010). Laim-borelioz: kliniko-imunopatohenetychni osoblyvosti ta ekstrene preventyvne likuvannia [Lyme borreliosis: clinical and immunopathogenetic features and emergency preventive treatment]. Extended abstract of Doctor’s thesis. Kyiv [in Ukrainian].
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Published
2021-08-20
How to Cite
Malysh, T. (2021). CLINICAL AND NEUROLOGICAL PECULIARITIES OF LYME DISEASE. Scientific Journal of Polonia University, 44(1), 269-277. https://doi.org/10.23856/4432
Section
HEALTH, ENVIRONMENT, DEVELOPMENT
