THE MAIN PARAMETERS OF IRON METABOLISM IN PATIENTS WITH UROTELIAL BLADDER CANCER AT DIFFERENT DEVELOPMENT STAGES OF MALIGNANT NEOPLASM ANEMIA

Keywords: ferritin, physiological role, clinical significance, blood serum

Abstract

The article presents information about the protein responsible for the iron depot in the body – ferritin. Its physiological role and clinical significance are demonstrated. A batophenanthroline method was used to determine the range of iron in the blood serum and the range of the total iron-binding capacity of the blood serum. The range of unsaturated iron-binding capacity of blood serum was calculated as the difference between total iron-binding capacity in blood serum and the range of iron in blood serum. The transferrin saturation coefficient of iron was defined as the ratio of the content of iron in blood serum to the total iron-binding capacity in blood serum. The range of transferrin was determined by the rate of the total iron-binding capacity in blood serum, and ferritin using the radiometric method. The dynamics of changes in ferritin content in malignant neoplasm anemia in patients with bladder cancer has been demonstrated. The conclusion about the importance of this parameter for laboratory diagnosis of iron deficiency and anemia of malignant neoplasms is made.

References

1. Andriiaka, A. A. (2018). Anemia zlokachestvennogo obrazovanija: osobennosti vedenija pazientov [Anemia of malignant neoplasm: peculiarities of patient management]. Hematologija. Transfusiologija. Vostochnaja Evropa – Hematology. Transfusiology. Eastern Europe, 2, 223 – 229 [in Russian].
2. Green, J. P. (eds.) (2014). Wintrobe’s clinical hematology. Philadelphia: Lippincott Williams& Wilkins.
3. Fedorenko, Z. P., Kolesnik, O. O., Gulak, L. O. (2019). Cancer in Ukraine, 2017-2018. Morbidity, mortality, indicators of efficiency of oncology service. Bulletin of the National Cancer Registry of Ukraine. Issue No. 20. Kyiv: PE Polyum.
4. Khalafian, A. A. (2014) Sovremennye statisticheskije metody v medizinskih issledovanijach: monografija [Modern statistical methods of medical research: monograph]. Moskow, Russia: N. p. [in Russian].
5. Linchevskii, O. V., Kovaliov, O. O., Kolesnyk, O. O., Beznosenko, A. P. (2019) Zlojakisni novoutvorennja v Ukraini (analityko-statystychnyi dovidnyk) [Malignant neoplasms in Ukraine (analytical and statistical reference book)]. Praktycna onkologia – Practical Oncology. 2, 59–118 [in Ukrainian].
6. Popovych, M. Yu. (2020). Zhelezodefizitnaia anemia: ozenka statusa zheleza v organizme po urovniu syvorotochnogo ferritina s uchetom rekomendazii VOZ (2020) [Iron deficiency anemia: Assesment of iron status in the human body by serum ferritin level, taking into account WHO recommendations (2020)]. Hematologija. Transfusiologija. Vostochnaja Evropa – Hematology. Transfusiology. Eastern Europe, 4, 479-488 [in Russian].
7. Titov, E. V. (2018). Sovremennyje metody diagnostiki i prognosa urotelialnogo raka mochevogo pusyria [Modern methods of diagnosis and prognosis of urothelial bladder cancer]. Problemy bezperervnoi medychnoi osvity ta nauky – Problems of Uninterrupted Medical Training and Science, 2, 86-91 [in Russian].
8. Wick, M., Pinggera, W., Lehmann, P. (1995). Ferritin in iron metabolism: Diagnosis of anemias (2nd ed. rev.). Wien, New York: Springer.

Abstract views: 374
PDF Downloads: 121
Published
2021-06-18
How to Cite
Borysenko, D., & Vydyborets, S. (2021). THE MAIN PARAMETERS OF IRON METABOLISM IN PATIENTS WITH UROTELIAL BLADDER CANCER AT DIFFERENT DEVELOPMENT STAGES OF MALIGNANT NEOPLASM ANEMIA. Scientific Journal of Polonia University, 43(6), 247-255. https://doi.org/10.23856/4332
Section
HEALTH, ENVIRONMENT, DEVELOPMENT