DIAGNOSTIC AND PROGNOSTIC VALUE OF MEASURING SEROTONIN IN MALIGNANT TUMOR ANEMIA IN PATIENT WITH COLORECTAL CANCER
Abstract
Colorectal cancer is an extremely urgent issue in modern medicine. This disease is often complicated by anemia, which has specific pathogenetic mechanisms of development and forms a mutual burden syndrome of diseases in cancer patients. The anemic syndrome is accompanied by the development of tissue hypoxia, which in turn activates the processes of oxidative stress and leads to increased release of biologically active compounds, in particular, biogenic amines. One of these is serotonin. Moderate concentrations of serotonin cause dilation of arterioles, reduction of myositis in venule walls, accompanied by venous stasis. Its high concentrations cause spasm of the arterioles, which exacerbates tissue hypoxia. We have examined 153 patients with colorectal cancer without anemia, 75 patients with colorectal cancer complicated by malignant tumor anemia, and 53 patients with iron deficiency anemia. The content of plasma free serotonin fractions was determined by the fluorometric method proposed by Mikhailychenko, B. V., Vydyborets, S. V. (1999). The patients with iron deficiency anemia and malignant tumor anemia have shown to have a significant increase in plasma free serotonin, compared with the control group and the group of patients with colorectal cancer without anemia. Plasma free serotonin was increasing together with the severity of anemia. The article discusses the feasibility of using the content of plasma free serotonin, as an option, to assess the state of compensation of secondary metabolic disorders in iron deficiency anemia and malignant tumor anemia during treatment and its possible differential diagnostic value.
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