DIAGNOSTIC AND PROGNOSTIC VALUE OF MEASURING SEROTONIN IN MALIGNANT TUMOR ANEMIA IN PATIENT WITH COLORECTAL CANCER

Keywords: anemic syndrome, hypoxia, biogenic amines, blood plasma

Abstract

Colorectal cancer is an extremely urgent issue in modern medicine. This disease is often complicated by anemia, which has specific pathogenetic mechanisms of development and forms a mutual burden syndrome of diseases in cancer patients. The anemic syndrome is accompanied by the development of tissue hypoxia, which in turn activates the processes of oxidative stress and leads to increased release of biologically active compounds, in particular, biogenic amines. One of these is serotonin. Moderate concentrations of serotonin cause dilation of arterioles, reduction of myositis in venule walls, accompanied by venous stasis. Its high concentrations cause spasm of the arterioles, which exacerbates tissue hypoxia. We have examined 153 patients with colorectal cancer without anemia, 75 patients with colorectal cancer complicated by malignant tumor anemia, and 53 patients with iron deficiency anemia. The content of plasma free serotonin fractions was determined by the fluorometric method proposed by Mikhailychenko, B. V., Vydyborets, S. V. (1999). The patients with iron deficiency anemia and malignant tumor anemia have shown to have a significant increase in plasma free serotonin, compared with the control group and the group of patients with colorectal cancer without anemia. Plasma free serotonin was increasing together with the severity of anemia. The article discusses the feasibility of using the content of plasma free serotonin, as an option, to assess the state of compensation of secondary metabolic disorders in iron deficiency anemia and malignant tumor anemia during treatment and its possible differential diagnostic value.

References

1. Back, M., Yurdagul, A., Tabas, I., Oorni, K., & Kovanen, P.T. (2019). Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nature Reviews Cardiology, 16, 389-406.
2. Belagaje, S. R. (2017). Stroke rehabilitation. CONTINIUM: Lifelong Learning in Neurology, 1, 238-253.
3. Cerqueira, N. F., Hussni, C. A., & Yoshida, W. B. (2005). Pathophysiology of mesenteric ischemia/
4. reperfusion: a review. Acta Cirurgica Brasileira, 4, 336-343.
5. El-Merahbi, R., Loffer, M., Mayer, A. & Sumara, G. (2015). The roles of peripheral serotonin in methabolic homeostasis. FEBS Letters, 15, 1728-1734.
6. Fedorenko, Z. P., Kolesnik, O. O., Gulak, I. O., Ryzhov, A. Yu., Sumkina, O. V. (2019). Kolorektalnyi rak v Ukraini: epidemiologichni ta organizatsijni aspekty problemy [Colorectal cancer in Ukraine: the epidemiological and organizational aspects of the problem]. Prakticna onkologia – Practical oncology. 2, 9-16 [in Ukrainian].
7. Gaidukova, S., Tkachenko, E., Bublij Yu. (2018). Vliiaet li soderzhanije svobodnych frakcij biogennyh aminov v plasme krovi na chastotu nevrologicheskih obschemozgovyh simptomov pri istinnoj policitemii i simptomaticheskih eritrocitozah [Does the content of free fractions of biogenic amines in the blood plasma affect the frequency of neurologic general cerebral symptoms in true polycythemia and symptomatic erythrocytosis?]. Hematologija. Transfusiologija. Vostochnaja Evropa – Hematology. Transfusiology. Eastern Europe. 3, 331-338 [in Russian].
8. Jang, S. H., Kwon, Y. M., & Chang, M. C. (2015) Serotonin syndrome in stroke patients. Journal of Rehabilitation Medicine, 3, 282-285.
9. Lopez, J. A. G., Brown, B. P., Armstrong, M. I., Piegors, D. J. & Heistad, D. D. (1989) Response of the mesenteric circulation to serotonin in normal and atherosclerotic monkeys: implications for the pathogenesis of non-occlusive intestinal ischaemia. Cardiovascular research, 2, 117-124.
10. Martin, A. M., Young, R. L., Leong, L., Rogers, G. B., Spencer, N. J., Jessup, C. F., & Keating, D. J. (2017). The diverse metabolic roles of peripheral serotonin. Endocrinology, 5, 1049-1063.
11. Mauler, M., Bode, C. & Duerschmied, D. (2016). Platelet serotonin modulates immune functions. Hamostaseologie, 1, 11-16.
12. Michailichenko, B. V. & Vydyborets, S. V. (1999). Metod odnochasnogo fluorymetrychnogo vyznachennja biogennych aminiv v analizovanij probi biosubstratu [The metod of simultaneousfluorimetric assay of biogenic amines in biological speciments]. Laboratornaja diagnostika – Laboratory Diagnostics, 2, 58-61. [in Ukrainian].
13. Moore, H. M., Drucker, N. A., Hosfield, B. D., Shelley, W. C. & Markel, T. F. (2020) Sildenafil as a Resurse Agent Following Intestinal Ischemia and Reperfusion Injury. Journal of Surgical Research, 246, 512-518.
14. Mortensen, J. K., Kranglung, K. L., Jonsen, S. P., Mors, O., Andersen, G., & Buttenschon, H. N. (2018). The serotonin transporter gene polymorphisms and risk of isschemic stroke. Cerebrovascular Diseases, 3-4, 187-192.
15. Oh, C. M., Namkung, J., Go, Y., Shong, K. E., Kim, K., H., & Shong, M. (2015). Regulation of systemic energy homeostasis by serotonin in adipose tissues. Nature communications, 10, 1-12.
16. Shchur, O. I. (2014). Dynamika rivnya serotoninu pry himichnomu neirolisysi v patsientiv iz kolorektalnym rakom [Dynamics of serotonin level at chemical neurolysis in patients with colorectal cancer]. Medicina naotloznyh sostoanij – Emergency medicine, 5, 82-85 [in Ukrainian].
17. Toth, S., Jonecova, Z., Varga, J., Stasko, P., Kovavalcinova, B., Maretta., M. & Vesela, J. (2012). Mesenteric ischemia-reperfusion injury: specific impact on different cell populations within the jejunal wall in rats. Acta Histochemica, 3, 276-284.
18. Watanabe, H., Akasaka, D., Ogasawara, H., Sato, K., Miyake, M., Saito, K., … & Chao, G. (2010). Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover. Endocrinology, 10, 4776-4786.
19. Xu, L., Cheng, D., Huang, Z., Ding, S., Zhang, W., Tan, H., … & Yang, X. (2017). Histamine promotes the differentiation of macrophages from CD11b+ myeloid cells and formation of foam cells through a Stat6-dependent pathway. Atherosclerosis, 263, 42-52.
20. Yabut, J. V., Crane, J. D., Green, A. E., Keating, D. G., Khan, W. I., & Steinberg, G. R. (2019). Emerging roles for serotonin in regulating metabolism: New implications for an ancient molecule. Endocrine reviews, 4, 1092-1107.

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Published
2021-08-20
How to Cite
Andriiaka, A., & Vydyborets, S. (2021). DIAGNOSTIC AND PROGNOSTIC VALUE OF MEASURING SEROTONIN IN MALIGNANT TUMOR ANEMIA IN PATIENT WITH COLORECTAL CANCER. Scientific Journal of Polonia University, 44(1), 235-244. https://doi.org/10.23856/4428
Section
HEALTH, ENVIRONMENT, DEVELOPMENT