EFFECT OF MELATONIN ON FIBRINIOLYSIS IN THE BRAIN OF RATS WITH DEXAMETHASONE DIABETES

Abstrakt

The purpose of our study was to determine the effect of melatonin on the characteristics of fibrinolysis in the brain of rats with dexamethasone diabetes. Materials and Methods. The experimental study was carried out on thirty male eighteen- month-old non-linear white rats. The experimental rats were divided into three groups: 1) intact animals (control group); 2) rats with untreated dexamethasone diabetes; 3) rats, what were administered by melatonin in a dose of 10 mg per kg of body weight intragastrically daily through a metal probe during the 13 days of experiment in addition to dexamethasone injection. Results. In the cerebral cortex of rats with diabetic neurodegeneration on the 14th day of the experiment, an increase in total fibrinolysis due to enzymatic fibrinolysis was found. Thus, TFA increased by 10%, and EFA by 15% compare to the indicators of animals of the control group. In the hippocampus, NFA indicators did not change, and EFA increased by 25% compared to the indicators of control group. Daily oral administration of melatonin (10 mg/kg) to rats with diabetes-induced neurodegeneration did not significantly affect the EFA index in the cerebral cortex, but contributed to a 15% decrease in this indicator in the hippocampus, compared to the indicators of diabetic rats that did not receive any correction agents. The indicators of TFA and NFA both in the cerebral cortex and in the hippocampus were not significantly different from the indicators of rats with diabetes. Conclusions. A decrease in the intensity of the fibrinolysis process was noted in the cerebral cortex and hippocampus of rats that, in addition to dexamethasone injections, were orally administered melatonin daily for 13 days.