THE NEED TO ADMINISTER ANTIBIOTIC THERAPY FOR SEPTIC SHOCK DURING TRANSPORTATION TO THE EMERGENCY DEPARTMENT FOR MORE THAN AN HOUR
Abstrakt
The article compares different views on empirical antibiotic therapy during the first hourfrom the onset of suspected septic shock to the patient's transportation to the emergency department.The article is based on protocols and clinical guidelines from the Ministry of Health ofUkraine (MoH), Infectious Diseases Society of America (IDSA), and Society of Critical CareMedicine (SCCM). The aim of the study is to determine the feasibility of antibiotic therapy for septic shockwithin the first hour of its onset based on studies by foreign authors, comparison of protocolsand clinical guidelines from the Ministry of Health of Ukraine (MoH), Infectious DiseasesSociety of America (IDSA) and Society of Crirtical Care Medicine (SCCM). To determine theoptimal antibiotic regimen to prevent patient death based on the recommendations of the Ministryof Health of Ukraine and the Society of Critical Care Medicine (SCCM).Materials and methods. The following methods were used in the study: content analysis,comparative analysis and systematization of the research material. The study was conductedbased on the study of clinical guidelines and protocols of the Ministry of Health ofUkraine (MoH), Infectious Diseases Society of America (IDSA) and Society of Criminal CareMedicine (SCCM), as well as publications of foreign authors. The search was conducted on thebasis of PubMed and Google Scholar databases in 2017–2023.Results. According to the results of many scientists from around the world Ferrer R.(2014), Liu V. (2017), Singer M. (2017), Sherwin R. and co-authors (2017), Bloos F. (2017),Johnston A. (2017), Whiles B. (2017), Kim R. (2018), Sung W. (2020), Rothrock S. (2020),Sankar J. (2021), Asner S. (2021), Al-Kader D. (2022) Bisarya R. (2022) found that each additionalhour of delayed antibiotic administration from triage to drug administration leads to an8% to 34% increase in mortality among patients with septic shock before drug administration.Patients with a suspected septic process should receive antibiotics as soon as possible afterdiagnosis, otherwise the chances of complications in the form of septic shock increase witheach passing hour.Conclusions. Antibiotic therapy for suspected sepsis or septic shock should be started asearly as possible, but the recommendations of the IDSA and other studies should also be takeninto account to reduce complications and deaths caused by septic shock.
Wykaz bibliografii
2. Urgent medicare: Dogospital'niy the stage. New clinical protocol in obedience to the order of MOZ of Ukraine from 05.06.2019 № 1269. URL: https://www.dec.gov.ua/wp-content/uploads/2020/07/2019_1269_nkp_ekstren_ditdor.pdf
3. Chorna, V.V. [et al]. (2023). Еxpediency of antibiotic therapy in case of septic shock, if the time of transport to the emergency department is more than 1 hour. Prospects and innovations of science, Series" Medicine ", Vols.10 ( 28 ). Р. 834-845
4. Surviving Sepsis Campaign Guidelines 2021. URL: https://www.sccm.org/Clinical-Resources/Guidelines/Guidelines/Surviving-Sepsis-Guidelines-2021#Recommendations.
5. Liu, V.X , Fielding-Singh, V., Greene, J. et al. (2017). The Timing of Early Antibiotics and Hospital Mortality in Sepsis. Am J Respir Crit Care Med. Vols.196(7). P. 856-863. https://doi.org /10.1164/rccm.201609-1848OC.
6. Masur, H., Chief. (2018). Infectious Diseases Society of America (IDSA) POSITION STATEMENT: Why IDSA Did Not Endorse the Surviving Sepsis Campaign Guidelines Clin. Infect Dis. Vols. 66(10). P. 1631–1635. https://doi.org /10.1093/cid/cix997.
7. Singer, M. (2017). Antibiotics for Sepsis: Does Each Hour Really Count, or Is It Incestuous Amplification? Am J Respir Crit Care Med. Vols. 196(7). P.800-802. https://doi.org/ 10.1164/rccm.201703-0621ED.
8. Schmidt, G.A , Mandel, M. (2023). Evaluation and management of suspected sepsis and septic shock in adults. URL: https://www.uptodate.com/contents/evaluation-and-managementof-suspected-sepsis-and-septic-shock-in-adults
9. Sherwin, R., Winters, M., Vilke, G.M. (2017). [Does Early and Appropriate Antibiotic Administration Improve Mortality in Emergency Department Patients with Severe Sepsis or Septic Shock?] J Emerg Med. Vols. 53(4). P. 588-595. https://doi.org/ 10.1016/j.jemermed.2016.12.009.
10. Ferrer, R., Martin-Loeches, I., Phillips, G. et al. (2014). Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program Crit Care Med. Vols. 42(8). P. 1749–55. https://doi.org/ 10.1097/CCM.0000000000000330.
11. Bloos, F., Rüddel, H., Thomas-Rüddel, D. еt al. (2017). Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomized trial. Intensive Care Med. Vols. 43(11). P. 1602-1612. https://doi.org/ 10.1007/s00134-017-4782-4.
12. Kalil, A., Gilbert, D., Winslow, D., et al. (2018). Infectious Diseases Society of America (IDSA) POSITION STATEMENT: Why IDSA Did Not Endorse the Surviving Sepsis Campaign Guidelines. Clin Infect Dis. Vols. 66(10). P. 1631–1635. https://doi.org /10.1093/cid/cix997
13. Whiles, B., Deis, A.S., Simpson, S.Q. et al. (2017). Increased Time to Initial Antimicrobial Administration Is Associated With Progression to Septic Shock in Severe Sepsis Patients. Crit Care Med. Vols. 45(4). P. 623-629. https://doi.org/ 10.1097/CCM.0000000000002262.
14. Al-Kader, D.A., Anwar, S., Hussaini, Н., et al. (2022). Systematic Review on the Effects of Prompt Antibiotic Treatment on Survival in Septic Shock and Sepsis Patients in Different Hospital Settings. Cureus. Vols. 14(12): e32405. doi: 10.7759/cureus.32405
15. Asner, S.A., Desgranges, F., Schrijver, I.T., et al. (2021). Impact of the timeliness of antibiotic therapy on the outcome of patients with sepsis and septic shock. J Infect. Vols. 82(5). P. 125–134. https://doi.org/10.1016/j.jinf.2021.03.003. DOI: 10.1016/j.jinf.2021.03.003
16. Sankar, J., Garg, M., Ghimire, J. J., et al. (2021). Delayed Administration of Antibiotics Beyond the First Hour of Recognition Is Associated with Increased Mortality Rates in Children with Sepsis/Severe Sepsis and Septic Shock. J Pediatr. Vols. 233. P. 183–190.e3. https://doi.org/10.1016/j.jpeds.2020.12.035.
17. Ko Sung, В., Choi, S.-H., Kang, G.H., et al. (2020). Time to Antibiotics and the Outcome of Patients with Septic Shock: A Propensity Score Analysis. Am J Med. Vols. 133(4). P. 485–491. e4. https://doi.org/10.1016/j.amjmed.2019.09.012
18. Rothrock, S.G., Cassidy, D.D., Barneck, M., et al. (2020). Outcome of Immediate Versus Early Antibiotics in Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis. Ann Emerg Med. Vols. 76(4). P. 427–441. https://doi.org /10.1016/j.annemergmed.2020.04.042
19. Johnston, A.N., Park, J., Doi, S.A. (2017). Effect of Immediate Administration of Antibiotics in Patients With Sepsis in Tertiary Care: A Systematic Review and Meta-analysis. Clin Ther. Vols. 39(1). P. 190–202.e6. https://doi.org/10.1016/j.clinthera.2016.12.003
20. Bisarya, R., Song, X., Salle, J., et al., (2022). Antibiotic Timing and Progression to Septic Shock Among Patients in the ED With Suspected Infection. Chest. Vols. 161(1). P. 112–120. https://doi.org/10.1016/j.chest.2021.06.029
21. Kim. R., Y, Ng. A.M., Persaud. A., et al. (2018). Antibiotic Timing and Outcomes in Sepsis. Am J Med Sci. Vols. 355(6). P. 524–529. https://doi.org/10.1016/j.amjms.2018.02.007.
Abstract views: 50 PDF Downloads: 36
